Gengraf Capsules and Sevelamer Powder Packets

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Sevelamer may reduce the blood levels and effects of cycloSPORINE. Contact your doctor if your condition changes during treatment with these medications. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with sevelamer may reduce blood levels of oral cyclosporine, mycophenolate mofetil, and tacrolimus. The mechanism is reduction of absorption by sevelamer. Concomitant use of sevelamer with mycophenolate mofetil in adult and pediatric patients decreased the mean Cmax and AUC of mycophenolic acid (MPA) by 36% and 26%, respectively. Adverse effects, such as graft rejection in transplant patients, have not been reported. Data are lacking for an interaction with other phosphate binders.

MANAGEMENT: The immunosuppressant may be given at least 1 to 2 hours before or 2 to 3 hours after sevelamer administration to minimize the impact on absorption. It is recommended to closely monitor blood concentrations of the immunosuppressant during concomitant use and after discontinuation of sevelamer.

Gengraf Capsules

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Gengraf (Capsules, Modified), Gengraf

What is Gengraf Capsules?

Sevelamer Powder Packets

Generic Name: sevelamer

Brand name: Renagel, Renvela

Synonyms: Sevelamer

What is Sevelamer Powder Packets?