Gengraf Capsules and Sofosbuvir, velpatasvir, and voxilaprevir

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

CycloSPORINE may significantly increase the blood levels of voxilaprevir, the safety of which has not been established. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with cyclosporine may significantly increase the plasma concentrations of voxilaprevir. The proposed mechanism is inhibition of organic anion transporting polypeptide (OATP) 1B1-mediated hepatic uptake of voxilaprevir by cyclosporine. Inhibition of P-glycoprotein (P-gp)- and breast cancer resistance protein (BCRP)-mediated intestinal transport and CYP450 3A4-mediated metabolism of voxilaprevir may also contribute. When a single 100 mg dose of voxilaprevir was administered with a single 600 mg dose of cyclosporine to 24 study subjects, mean voxilaprevir peak plasma concentration (Cmax) and systemic exposure (AUC) increased by approximately 19.0- and 9.4-fold, respectively. The safety of such high levels of voxilaprevir has not been established. Voxilaprevir had no significant effects on the pharmacokinetics of cyclosporine.

MANAGEMENT: Concomitant use of voxilaprevir with cyclosporine is not recommended.

Gengraf Capsules

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Gengraf (Capsules, Modified), Gengraf

What is Gengraf Capsules?

Sofosbuvir, velpatasvir, and voxilaprevir

Generic Name: sofosbuvir / velpatasvir / voxilaprevir

Brand name: Vosevi

Synonyms: Sofosbuvir, Velpatasvir, and Voxilaprevir

What is Sofosbuvir, velpatasvir, and voxilaprevir?