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Gengraf Capsules and Succinylcholine

Determining the interaction of Gengraf Capsules and Succinylcholine and the possibility of their joint administration.

Check result:

Gengraf Capsules <> Succinylcholine

Relevance: 22.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using succinylcholine together with cycloSPORINE can prolong the effects of succinylcholine. You should be closely monitored for prolong breathing cessation and respiratory paralysis after use of cycloSPORINE. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Cyclosporine may enhance and prolong the neuromuscular blockade of the nondepolarizing skeletal muscle relaxants. The mechanism is unknown.

MANAGEMENT: Patients should be monitored for excessive and/or prolonged neuromuscular blockade.

References

Wood GG "Cyclosporin-vercuronium interaction." Can J Anaesth 36 (1989): 358-66
Crosby E, Robblee JA "Cyclosporine-pancuronium interaction in a patient with a renal allograft." Can J Anaesth 35 (1988): 300-2
Sidi A, Kaplan RF, Davis RF "Prolonged neuromuscular blockade and ventilatory failure after renal transplantation and cyclosporine." Can J Anaesth 37 (1990): 543-8
Sharpe MD, Gelb AW "Cyclosporin potentiates vercuronium blockade and prolongs recovery time in humans." Can J Anaesth 39 (1992): a126

Gengraf Capsules

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Gengraf (Capsules, Modified), Gengraf

What is Gengraf Capsules?

Succinylcholine

Generic Name: succinylcholine

Brand name: Anectine, Quelicin

Synonyms: n.a.

What is Succinylcholine?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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