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Gengraf Capsules and Sulfasalazine Delayed-Release Tablets

Determining the interaction of Gengraf Capsules and Sulfasalazine Delayed-Release Tablets and the possibility of their joint administration.

Check result:

Gengraf Capsules <> Sulfasalazine Delayed-Release Tablets

Relevance: 22.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using cycloSPORINE and sulfaSALAzine together can add to the risk of organ rejection associated with low cycloSPORINE levels. This combination can also increase your risk of dangerous side effects on your kidneys. If your doctor does prescribe these medications together, you may need a dose adjustment or special tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR CLOSELY: Sulfonamides may significantly reduce serum cyclosporine concentrations by an unknown mechanism. Allograft rejections have resulted. Hyperkalemia and additive nephrotoxicity has also been reported. The mechanism is unknown. Data are available for intravenous trimethoprim-sulfamethoxazole, intravenous sulfamethazine (no longer marketed), oral sulfadiazine, and sulfasalazine. Oral trimethoprim-sulfamethoxazole reportedly does not affect cyclosporine levels.

MANAGEMENT: Renal function and cyclosporine levels should be closely monitored if these drugs must be used concomitantly.

References

Cockburn IT, Krupp P "An appraisal of drug interactions with sandimmun." Transplant Proc 21 (1989): 3845-50
Jones DK, Hakim M, Wallwork J, Higenbottam TW "Serious interaction between cyclosporin A and sulphadimidine." Br Med J 292 (1986): 728-9
Ringden O, Myrenfors P, Klintmalm G, Tyden G, Ost L "Nephrotoxicity by co-trimoxazole and cyclosporin in transplanted patients." Lancet 1 (1984): 1016-7
Wallwork J, McGregor CG, Wells FC, Cory-Pearace R, English TA "Cyclosporin and intravenous sulphadimidine and trimethoprim therapy." Lancet 1 (1983): 326-7
Berg K, Gjellestad A, Nordby G, et al "Renal effects of trimethoprim in ciclosporin- and azathioprine-treated kidney-allografted patients." Nephron 53 (1989): 218-22
DuCheyron D, Debruyne D, Lobbedez T, Richer C, Ryckelynck JP, deLigny BH "Effect of sulfasalazine on cyclosporin blood concentration." Eur J Clin Pharmacol 55 (1999): 227-8
Wallwork J, McGregor CG, Wells FC, et al "Cyclosporin and intravenous sulphadimidine and trimethoprim therapy." Lancet 02/12/83 (1983): 366-7
Spes CH, Angermann CE, Stempfle HU, et al "Sulfadiazine therapy for toxoplasmosis in heart transplant recipients decreases cyclosporine concentration." Clin Investig 70 (1992): 752-4
Yee GC, McGuire TR "Pharmacokinetic drug interactions with cyclosporin (Part I)." Clin Pharmacokinet 19 (1990): 319-32

Gengraf Capsules

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Gengraf (Capsules, Modified), Gengraf

What is Gengraf Capsules?

Sulfasalazine Delayed-Release Tablets

Generic Name: sulfasalazine

Brand name: Azulfidine, Azulfidine EN-tabs, Sulfazine

Synonyms: Sulfasalazine, SulfaSALAzine

What is Sulfasalazine Delayed-Release Tablets?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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