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Gengraf Capsules and Trimethoprim

Determining the interaction of Gengraf Capsules and Trimethoprim and the possibility of their joint administration.

Check result:

Gengraf Capsules <> Trimethoprim

Relevance: 22.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using trimethoprim together with cycloSPORINE may decrease the effects of cycloSPORINE. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Increased serum creatinine levels and decreased efficacy of cyclosporine have been reported when administered concurrently with trimethoprim. The mechanism of this interaction is unknown.

MANAGEMENT: Caution is advised if these medications must be used concomitantly. The patient's renal function and efficacy and safety of both drugs should be monitored during concomitant administration. Use of an alternative antibiotic may be appropriate.

References

Ringden O, Myrenfors P, Klintmalm G, Tyden G, Ost L "Nephrotoxicity by co-trimoxazole and cyclosporin in transplanted patients." Lancet 1 (1984): 1016-7
Thompson JF, Chalmers DH, Hunnisett AG, et al "Nephrotoxicity of trimethoprim and cotrimoxazole in renal allograft recipients treated with cyclosporine." Transplantation 36 (1983): 204-6
Wallwork J, McGregor CG, Wells FC, Cory-Pearace R, English TA "Cyclosporin and intravenous sulphadimidine and trimethoprim therapy." Lancet 1 (1983): 326-7
Berg K, Nordby G, Rootwelt K, et al "Effects on renal function of combined treatment with trimethoprim and cyclosporine A in kidney transplant patients." Transplant Proc 20 (1988): 413-5

Gengraf Capsules

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Gengraf (Capsules, Modified), Gengraf

What is Gengraf Capsules?

Trimethoprim

Generic Name: trimethoprim

Brand name: Primsol, Trimpex, Proloprim

Synonyms: n.a.

What is Trimethoprim?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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