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Gengraf Capsules and Unipen

Determining the interaction of Gengraf Capsules and Unipen and the possibility of their joint administration.

Check result:

Gengraf Capsules <> Unipen

Relevance: 22.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using nafcillin together with cycloSPORINE may decrease the effects of cycloSPORINE. Contact your doctor if your condition changes. If your doctor prescribes these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Nafcillin may decrease serum cyclosporine concentrations by an unknown mechanism and may result in subtherapeutic cyclosporine levels. The risk of rejection may be increased in transplant patients.

MANAGEMENT: Given the risk of organ rejection associated with inadequate immunosuppressant levels, caution is advised if cyclosporine must be coadministered with nafcillin. Cyclosporine blood levels should be closely monitored and the dosage adjusted accordingly.

References

Veremis SA, Maddux MS, Pollak R, Mozes MF "Subtherapeutic cyclosporine concentrations during nafcillin therapy." Transplantation 43 (1987): 913-5
"Product Information. Sandimmune (cyclosporine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
Cockburn IT, Krupp P "An appraisal of drug interactions with sandimmun." Transplant Proc 21 (1989): 3845-50

Gengraf Capsules

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Gengraf (Capsules, Modified), Gengraf

What is Gengraf Capsules?

Unipen

Generic Name: nafcillin

Brand name: Unipen, Nallpen

Synonyms: n.a.

What is Unipen?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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