Gengraf Capsules and Voriconazole Tablets

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Voriconazole may increase the blood levels and effects of cycloSPORINE. You may need a dose adjustment if you have been taking cycloSPORINE and are starting treatment with voriconazole. Contact your doctor if your condition changes or if you experience increased side effects such as nausea, vomiting, diarrhea, abdominal pain, dizziness, fatigue, headache, tremors, seizures, fever, sore throat, unusual bruising or bleeding, and increased or decreased urination. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSE: Coadministration with voriconazole may increase the blood concentrations of cyclosporine. The mechanism is voriconazole inhibition of CYP450 3A4, the isoenzyme responsible for the metabolic clearance of cyclosporine. In seven renal transplant recipients stabilized on their cyclosporine regimen, voriconazole (200 mg every 12 hours for 7.5 days) increased the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of cyclosporine by 13% and 70%, respectively, compared to placebo. Six other subjects were discontinued from the study during voriconazole exposure due to safety concerns (elevated cyclosporine levels) and drug-related adverse effects that included elevated liver function tests, asthenia, dyspnea, and peripheral edema. These subjects had a mean 2.5-fold increase in cyclosporine plasma trough concentration (Cmin) compared to a mean increase of 1.7-fold in subjects who were not discontinued from the study. Although not serious, most causality-related adverse events occurred during voriconazole exposure and were attributable to elevated cyclosporine concentrations.

MANAGEMENT: Caution is advised if cyclosporine must be used concomitantly with voriconazole. Patients who are already receiving cyclosporine should have the dosage reduced to one-half the original dosage upon initiation of voriconazole therapy. Close monitoring of renal function and cyclosporine blood levels is recommended both following initiation and withdrawal of voriconazole therapy, and the cyclosporine dosage adjusted as necessary.

Gengraf Capsules

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Gengraf (Capsules, Modified), Gengraf

What is Gengraf Capsules?

Voriconazole Tablets

Generic Name: voriconazole

Brand name: Vfend, Vfend

Synonyms: Voriconazole (oral/injection), Voriconazole

What is Voriconazole Tablets?