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Gengraf (Cyclosporine Oral Solution, Modified) and Morgidox

Determining the interaction of Gengraf (Cyclosporine Oral Solution, Modified) and Morgidox and the possibility of their joint administration.

Check result:

Gengraf (Cyclosporine Oral Solution, Modified) <> Morgidox

Relevance: 01.12.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Doxycycline may increase cyclosporine serum concentrations by an unknown mechanism. Data are from a single unpublished case report in which the effects were reproduced upon rechallenge with doxycycline. Until more data are available, caution should be used with concomitant administration of these agents.

References

Cockburn IT, Krupp P "An appraisal of drug interactions with sandimmun." Transplant Proc 21 (1989): 3845-50
Cockburn I "Cyclosporine A: a clinical evaluation of drug interactions." Transplant Proc 18 (1986): 50-5

Gengraf (Cyclosporine Oral Solution, Modified)

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Gengraf (Capsules, Modified), Gengraf

What is Gengraf (Cyclosporine Oral Solution, Modified)?

Morgidox

Generic Name: doxycycline

Brand name: Acticlate, Adox Pak 2/100, Adoxa, Adoxa Pak 1/100, Adoxa Pak 1/150, Avidoxy, Monodox, Morgidox, Oraxyl, TargaDOX, Vibramycin, Adoxa CK, Adoxa Pak, Adoxa TT, Alodox, Avidoxy, Doryx, Mondoxyne NL, Oracea, Periostat Targadox, Vibramycin Calcium, Vibramycin Hyclate, Vibramycin monohydrate, Vibra-Tabs, Doxy 100, TargaDOX

Synonyms: n.a.

What is Morgidox?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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