Gengraf (Cyclosporine Oral Solution, Modified) and Vinblastine Intravenous
Determining the interaction of Gengraf (Cyclosporine Oral Solution, Modified) and Vinblastine Intravenous and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:An in vitro test has shown cyclosporine to have inhibitory effects on the biotransformation of vinblastine. Both drugs are believed to be metabolized by the liver cytochrome P-450. The clinical significance of this interaction has not been established. If cyclosporine and vinblastine are used concomitantly, caution and close observation are advised.
- Zhou-Pan XR, Seree E, Zhou XJ, et al "Involvement of human liver cytochrome P450 3A in vinblastine metabolism: drug interactions." Cancer Res 53 (1993): 5121-6
Generic Name: cyclosporine
Brand name: Gengraf, Neoral, Sandimmune, Sandimmune
Synonyms: Gengraf (Capsules, Modified), Gengraf
Generic Name: vinblastine
Brand name: Velban
Synonyms: Vinblastine, VinBLAStine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Gengraf (Cyclosporine Oral Solution, Modified)-Vinblastine Sulfate
- Gengraf (Cyclosporine Oral Solution, Modified)-Vincasar PFS
- Gengraf (Cyclosporine Oral Solution, Modified)-Vincristine
- Gengraf (Cyclosporine Oral Solution, Modified)-Vincristine (Liposomal)
- Gengraf (Cyclosporine Oral Solution, Modified)-Vincristine Intravenous
- Gengraf (Cyclosporine Oral Solution, Modified)-Vincristine liposome
- Vinblastine Intravenous-Gengraf Capsules
- Vinblastine Intravenous-Gengraf Oral
- Vinblastine Intravenous-Gengraf Oral Solution
- Vinblastine Intravenous-Genicin
- Vinblastine Intravenous-Genicin Vita-Q
- Vinblastine Intravenous-Genotropin