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Gengraf Oral and Nifedical XL

Determining the interaction of Gengraf Oral and Nifedical XL and the possibility of their joint administration.

Check result:

Gengraf Oral <> Nifedical XL

Relevance: 12.02.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using NIFEdipine together with cycloSPORINE may increase the effects of NIFEdipine. Contact your doctor if you experience dizziness, low blood pressure, fainting, headache, or lower extremity swelling. If your doctor prescribes these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Cyclosporine may increase serum concentrations of some dihydropyridine calcium channel blockers (CCBs). Serum CCB levels and the risk of side effects may be increased. Data are available for nifedipine. In addition, gingival hyperplasia has been reported with nifedipine and cyclosporine.

MANAGEMENT: Clinical and laboratory monitoring for altered efficacy and safety (e.g., increased cyclosporine levels, excessive hypotension, or nephrotoxicity) of the calcium channel blocker is recommended during concomitant therapy and when the dose of cyclosporine is changed or discontinued. CCB dosage adjustments may be required. Patients should be advised to notify their physician if they experience excessive CCB effects such as dizziness, excessive hypotension, syncope, headache, or lower extremity edema.

References

Sketris IS, Methot ME, Nicol D, Belitsky, Knox MG "Effect of calcium-channel blockers on cyclosporine clearance and use in renal transplant patients." Ann Pharmacother 28 (1994): 1227-31
"Product Information. Sandimmune (cyclosporine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
Harper SJ, Moorhouse J, Veitch PS, et al. "Improved immediate graft function with nifedipine in cyclosporine-treated renal allograft recipients--a randomized prospective study." Transplantation 54 (1992): 742-3
Jacobs U, Klein B, Klehr HU "Cumulative side effects of cyclosporine and ca antagonists: hypergalactinemia, mastadenoma, and gynecomastia." Transplant Proc 26 (1994): 3122
McFadden JP, Pontin JE, Powles AV, Fry L, Idle JR "Cyclosporin decreases nifedipine metabolism." Br Med J 299 (1989): 1244

Gengraf Oral

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Gengraf (Capsules, Modified), Gengraf

What is Gengraf Oral?

Nifedical XL

Generic Name: nifedipine

Brand name: Adalat CC, Afeditab CR, Nifediac CC, Nifedical XL, Procardia, Procardia XL, Adalat

Synonyms: Nifedical XL (Oral)

What is Nifedical XL?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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