Genotropin Miniquick and Geodon (Ziprasidone Capsules)
Determining the interaction of Genotropin Miniquick and Geodon (Ziprasidone Capsules) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with drugs that are inducers of the CYP450 3A4 isoenzyme may only modestly decrease the plasma concentrations of ziprasidone, as less than 1/3 of ziprasidone metabolic clearance occurs via oxidation mediated by CYP450 3A4. In nine healthy subjects, pretreatment with the potent CYP450 3A4 inducer carbamazepine (100 mg/day titrated to 400 mg/day over 5 days) for 25 days decreased the mean peak plasma concentration (Cmax) and 12-hour area under the concentration-time curve (AUC) of ziprasidone (20 mg orally twice a day for 3 days) by 27% and 36%, respectively, compared to when ziprasidone was administered alone. The half-life was decreased by 1 hour. These changes, although statistically significant, were not considered clinically important. There were also no serious adverse events or clinically significant alterations in ECG or vital signs throughout the study. These findings suggest that ziprasidone dose modifications are unlikely to be necessary in patients receiving potent CYP450 3A4 inducers.
- Miceli JJ, Anziano RJ, Robarge L, Hansen RA, Laurent A "The effect of carbamazepine on the steady-state pharmacokinetics of ziprasidone in healthy volunteers." Br J Clin Pharmacol 49(suppl 1) (2000): s65-70
- "Product Information. Geodon (ziprasidone)." Pfizer US Pharmaceuticals, New York, NY.
Generic Name: somatropin
Brand name: Genotropin, Humatrope, Norditropin FlexPro Pen, Nutropin AQ NuSpin 10, Nutropin AQ Pen 10 Cartridge, Omnitrope, Saizen, Serostim, Zomacton, Zorbtive, Genotropin Miniquick, Norditropin Nordiflex Pen, Tev-Tropin, Nutropin, Norditropin, Nutropin AQ, Nutropin Depot, Norditropin Cartridge, Saizen Click-Easy, Omnitrope Pen 5 Cartridge, HumatroPen, Omnitrope Pen 10 Cartridge, Nutropin AQ Pen 20 Cartridge, Nutropin AQ NuSpin 5, Nutropin AQ NuSpin 20, Saizen Kit
Synonyms: Genotropin
Generic Name: ziprasidone
Brand name: Geodon
Synonyms: Geodon
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Genotropin Miniquick-Geodon (Ziprasidone Injection)
- Genotropin Miniquick-Geodon Injection
- Genotropin Miniquick-Geodon Intramuscular
- Genotropin Miniquick-Geone Oral
- Genotropin Miniquick-Geravim
- Genotropin Miniquick-Geref
- Geodon (Ziprasidone Capsules)-Genpril
- Geodon (Ziprasidone Capsules)-Gentamicin
- Geodon (Ziprasidone Capsules)-Gentamicin (Systemic)
- Geodon (Ziprasidone Capsules)-Gentamicin and prednisolone ophthalmic
- Geodon (Ziprasidone Capsules)-Gentamicin Cream
- Geodon (Ziprasidone Capsules)-Gentamicin Injection