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Ginkgo biloba and Procardia XL

Determining the interaction of Ginkgo biloba and Procardia XL and the possibility of their joint administration.

Check result:

Ginkgo biloba <> Procardia XL

Relevance: 02.03.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Some products containing ginkgo may increase the levels of NIFEdipine in your body. The effects of NIFEdipine may be increased. Let your doctor know if you experience dizziness, lightheadedness, flushing, fainting, or swelling in the ankle or leg while taking these medications, as they may be symptoms caused by excessive effects of NIFEdipine. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with ginkgo or ginseng has been found to increase the plasma concentrations of nifedipine in one study. The mechanism of interaction is unknown. Nifedipine is a known substrate of CYP450 3A4; however, the effects of ginkgo or ginseng on CYP450 3A4 metabolism have not been established. Limited in vitro data suggest that certain formulations such as ginkgo leaf extract or Siberian ginseng whole plant or root extracts may possess some CYP450 3A4-inhibiting activity. In the nifedipine study, pretreatment with ginkgo biloba (120 mg/day) and ginseng (200 mg/day) for 18 days increased the mean plasma concentration (at 0.5 hour postdose) of a single 10 mg dose of nifedipine by 53% and 29%, respectively, compared to administration of nifedipine alone in 22 healthy volunteers. The specific formulations of ginkgo and ginseng used were not specified.

MANAGEMENT: Patients should consult a healthcare provider before taking any herbal or alternative medicine. Nifedipine dosage may require adjustment if an interaction is suspected.

References

Smith M, Lin KM, Zheng YP "An open trial of nifedipine-herb interactions: nifedipine with St. John's wort, ginseng, or Ginko biloba." Clin Pharmacol Ther 69 (2001): P86

Ginkgo biloba

Generic Name: ginkgo

Brand name: Ginkgo biloba, Gingko Biloba

Synonyms: n.a.

What is Ginkgo biloba?

Procardia XL

Generic Name: nifedipine

Brand name: Adalat CC, Procardia, Procardia XL, Afeditab CR, Nifediac CC, Nifedical XL, Adalat

Synonyms: n.a.

What is Procardia XL?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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