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Ginkgo biloba and Trazodone Hydrochloride

Determining the interaction of Ginkgo biloba and Trazodone Hydrochloride and the possibility of their joint administration.

Check result:

Ginkgo biloba <> Trazodone Hydrochloride

Relevance: 02.03.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using traZODone together with ginkgo may lead to increased side effects. This may be more likely to occur in older adults or those with a debilitating condition. Contact your doctor if you experience loss of muscle coordination and increased drowsiness. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: The coadministration of low-dose trazodone and ginkgo biloba was associated with the development of ataxia, drowsiness, and coma in an elderly patient with Alzheimer's disease. The patient had received a total of 100 mg trazodone and 320 mg ginkgo biloba in an approximately 50-hour period. The effects were reversed by flumazenil. The mechanism of interaction proposed by the investigators is a synergistic GABAergic effect due to partial agonistic action of ginkgo biloba at benzodiazepine binding sites and increased liberation of GABA by an active metabolite of trazodone. Ginkgo may also induce the metabolism of trazodone to this active metabolite. However, causality was not clearly determined due to the presence of a benzodiazepine, which had been discontinued the day before the trazodone was initiated.

MANAGEMENT: In general, patients should consult a healthcare provider before taking any herbal or alternative medicine. Caution may be appropriate when combining ginkgo products with trazodone, especially in the elderly. Patients should be advised of the potential for increased sedation or other central nervous system effects.

References

Galluzzi S, Zanetti O, Binetti G, Trabucchi M, Frisoni GB "Coma in a patient with Alzheimer's disease taking low dose trazodone and ginkgo biloba." J Neurol Neurosurg Psychiatry 68 (2000): 679-83
Izzo AA, Ernst E "Interactions between herbal medicines and prescribed drugs: a systematic review." Drugs 61 (2001): 2163-75

Ginkgo biloba

Generic Name: ginkgo

Brand name: Ginkgo biloba, Gingko Biloba

Synonyms: n.a.

What is Ginkgo biloba?

Trazodone Hydrochloride

Generic Name: trazodone

Brand name: Desyrel, Desyrel Dividose, Oleptro

Synonyms: Trazodone, TraZODone

What is Trazodone Hydrochloride?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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