Ginseng and Imatinib

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this interaction is not currently available.MONITOR CLOSELY: Coadministration of ginseng with imatinib may increase the plasma concentrations and risk of adverse effects associated with imatinib. The proposed mechanism involves inhibition by ginseng of the CYP450 3A4- and/or P-glycoprotein (P-gp)-mediated metabolism of imatinib. A case report describes a 26-year-old man with acute lobular hepatitis on biopsy. He had been taking imatinib 400 mg daily for 7 years with no complications, but over the previous 3 months, he had also been ingesting Panax ginseng daily via energy drinks. Imatinib was later restarted at the same dose with no recurrent elevations of liver enzymes. MANAGEMENT: Monitor patients closely for signs and symptoms of imatinib-induced toxicity (e.g., hepatotoxicity) during coadministration with ginseng. References Bilgi N, Bell K, Ananthakrishnan AN, Atallah E "Imatinib and Panax ginseng: a potential interaction resulting in liver toxicity." Ann Pharmacother 44 (2010): 926-8

MONITOR CLOSELY: Coadministration of ginseng with imatinib may increase the plasma concentrations and risk of adverse effects associated with imatinib. The proposed mechanism involves inhibition by ginseng of the CYP450 3A4- and/or P-glycoprotein (P-gp)-mediated metabolism of imatinib. A case report describes a 26-year-old man with acute lobular hepatitis on biopsy. He had been taking imatinib 400 mg daily for 7 years with no complications, but over the previous 3 months, he had also been ingesting Panax ginseng daily via energy drinks. Imatinib was later restarted at the same dose with no recurrent elevations of liver enzymes.

MANAGEMENT: Monitor patients closely for signs and symptoms of imatinib-induced toxicity (e.g., hepatotoxicity) during coadministration with ginseng.

Ginseng

Generic Name: ginseng

Brand name:

Synonyms: n.a.

What is Ginseng?

Imatinib

Generic Name: imatinib

Brand name: Gleevec

Synonyms: n.a.

What is Imatinib?