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Ginseng and Lanoxin Tablets

Determining the interaction of Ginseng and Lanoxin Tablets and the possibility of their joint administration.

Check result:
Ginseng <> Lanoxin Tablets
Relevance: 13.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using digoxin together with ginseng. Using digoxin together with ginseng can alter your blood levels of digoxin. Call your doctor if you have side effects such as fatigue, irregular heartbeats, abnormally fast or slow heartbeats, nausea, vomiting, seizures, hallucinations, green or yellow vision. If your doctor does prescribe these medications together, you may need a dose adjustment or special tests to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Asian and Siberian ginseng may interfere with digoxin either pharmacodynamically or with its monitoring via certain immunoassays. The interaction has been observed in vitro as well as in nondigoxin-treated mice that were fed ginseng and is thought to be due to substances in the ginseng that structurally resemble cardiac glycosides. Serum pools prepared from samples from patients receiving digoxin and then supplemented with Asian or Siberian ginseng also demonstrated interference. In one case report, a 74-year-old man who had been taking a constant dose of digoxin for many years was found during a routine office visit to have unexplained elevated serum digoxin level with no clinical signs of toxicity. The level remained high even after stopping the drug, whereupon the patient revealed that he had been taking a Siberian ginseng capsule. Soon after discontinuation of the capsules, serum digoxin returned to an acceptable level and therapy was resumed. Digoxin level again rose several months later when the patient resumed taking the ginseng but fell to within therapeutic range shortly after he stopped, despite continued therapy with digoxin at the same dosage. No analysis was performed to determine whether the capsules actually contained Siberian ginseng and if so, at what concentration.

MANAGEMENT: Patients should consult a healthcare provider before taking any herbal or alternative medicine. Use of ginseng should probably be avoided in patients treated with cardiac glycosides.

References
  • Miller LG "Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions." Arch Intern Med 158 (1998): 2200-11
  • Dasgupta A, Wu S, Actor J, Olsen M, Wells A, Datta P "Effect of Asian and Siberian ginseng on serum digoxin measurement by five digoxin immunoassays. Significant variation in digoxin-like immunoreactivity among commercial ginsengs." Am J Clin Pathol 119 (2003): 298-303
  • McRae S "Elevated serum digoxin levels in a patient taking digoxin and Siberian ginseng." CMAJ 155 (1996): 293-5
Ginseng

Generic Name: ginseng

Brand name:

Synonyms: n.a.

Lanoxin Tablets

Generic Name: digoxin

Brand name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin

Synonyms: Digoxin

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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