Glasdegib and Phenytoin Extended-Release Capsules
Determining the interaction of Glasdegib and Phenytoin Extended-Release Capsules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Phenytoin may significantly reduce the blood levels of glasdegib, which may make the medication less effective in treating your condition. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with potent inducers of CYP450 3A4 may significantly decrease the plasma concentrations of glasdegib, which is primarily metabolized by the isoenzyme. When glasdegib was coadministered with rifampin, a potent CYP450 3A4 inducer, glasdegib peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by 35% and 70%, respectively, compared to administration of glasdegib alone. Reduced efficacy of glasdegib may occur.
MANAGEMENT: Concomitant use of glasdegib with potent CYP450 3A4 inducers should generally be avoided.
- "Product Information. Daurismo (glasdegib)." Pfizer U.S. Pharmaceuticals Group, New York, NY.
Generic Name: phenytoin
Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt
Synonyms: Phenytoin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Glasdegib-Phenytoin Infatabs
- Glasdegib-Phenytoin injection
- Glasdegib-Phenytoin Intravenous
- Glasdegib-Phenytoin Oral Suspension
- Glasdegib-Phenytoin Sodium
- Glasdegib-Phenytoin Sodium, Prompt injection
- Phenytoin Extended-Release Capsules-Glasdegib Maleate
- Phenytoin Extended-Release Capsules-Glatiramer Acetate
- Phenytoin Extended-Release Capsules-Glatiramer injection
- Phenytoin Extended-Release Capsules-Glatiramer Subcutaneous
- Phenytoin Extended-Release Capsules-Glatopa
- Phenytoin Extended-Release Capsules-Glatopa injection