Glasdegib and Se-Donna PB Hyos
Determining the interaction of Glasdegib and Se-Donna PB Hyos and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:PHENobarbital may significantly reduce the blood levels of glasdegib, which may make the medication less effective in treating your condition. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with potent inducers of CYP450 3A4 may significantly decrease the plasma concentrations of glasdegib, which is primarily metabolized by the isoenzyme. When glasdegib was coadministered with rifampin, a potent CYP450 3A4 inducer, glasdegib peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by 35% and 70%, respectively, compared to administration of glasdegib alone. Reduced efficacy of glasdegib may occur.
MANAGEMENT: Concomitant use of glasdegib with potent CYP450 3A4 inducers should generally be avoided.
- "Product Information. Daurismo (glasdegib)." Pfizer U.S. Pharmaceuticals Group, New York, NY.
Generic Name: atropine / hyoscyamine / phenobarbital / scopolamine
Brand name: Donnatal, D-Tal, Phenohytro, Chardonna-2, Hyosophen, Donnapine, Elixiral, Bellatal, Spasmolin, Haponal, Antispas, Barbidonna, Donnatal Extentabs, Antispasmodic, Bellalphen, Donnaphen, Spasquid, Alkabel-SR, Bellatal ER, Servira, PB-Hyos, Quadrapax, Phenobarbital with Belladonna Alkaloids
Synonyms: Se-Donna PB Hyos (Oral), Se-Donna Pb Hyos
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Glasdegib-Se-Natal 19
- Glasdegib-Se-Plus Protein
- Glasdegib-Se-Tan DHA
- Glasdegib-Se-Tan Plus
- Glasdegib-Sea Buddies Daily Multiple Vitamin
- Glasdegib-Seasonale
- Se-Donna PB Hyos-Glasdegib Maleate
- Se-Donna PB Hyos-Glatiramer Acetate
- Se-Donna PB Hyos-Glatiramer injection
- Se-Donna PB Hyos-Glatiramer Subcutaneous
- Se-Donna PB Hyos-Glatopa
- Se-Donna PB Hyos-Glatopa injection