Glasdegib Maleate and Pentobarbital Sodium Injection
Determining the interaction of Glasdegib Maleate and Pentobarbital Sodium Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:PENTobarbital may reduce the blood levels of glasdegib, which may make the medication less effective in some cases. Contact your doctor if your symptoms worsen or your condition changes. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of glasdegib, which is primarily metabolized by the isoenzyme. When glasdegib was coadministered with rifampin, a potent CYP450 3A4 inducer, glasdegib peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by 35% and 70%, respectively, compared to administration of glasdegib alone. Reduced efficacy of glasdegib may occur. The interaction has not been studied with other, less potent inducers.
MANAGEMENT: The potential for diminished pharmacologic effects of glasdegib should be considered during coadministration with CYP450 3A4 inducers. Alternative treatments may be required if an interaction is suspected.
- "Product Information. Daurismo (glasdegib)." Pfizer U.S. Pharmaceuticals Group, New York, NY.
Generic Name: glasdegib
Brand name: Daurismo
Synonyms: Glasdegib
Generic Name: pentobarbital
Brand name: Nembutal Sodium, Nembutal
Synonyms: Pentobarbital (injection), PENTobarbital
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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