Gleevec and Jantoven

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ask your doctor before using warfarin together with imatinib. This can cause you to bleed more easily. You may need a dose adjustment in addition to testing of your prothrombin time or International Normalized Ratio (INR). Call your doctor promptly if you have any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Data from human liver microsome studies indicate that imatinib is a potent competitive inhibitor of the CYP450 2C9 isoenzyme. Although no formal clinical interaction studies have been performed, the coadministration of imatinib and warfarin is likely to result in elevated plasma concentrations and increased pharmacologic effects of warfarin due to inhibition of CYP450 2C9-mediated metabolism.

MANAGEMENT: The manufacturer recommends that patients treated with imatinib who require anticoagulation receive low molecular weight or standard heparin.

Gleevec

Generic Name: imatinib

Brand name: Gleevec

Synonyms: n.a.

What is Gleevec?

Jantoven

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

What is Jantoven?