Gliadel and Phenobarbital Sodium Injection
Determining the interaction of Gliadel and Phenobarbital Sodium Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:PHENobarbital may reduce the blood levels of carmustine, which may make the medication less effective in treating your condition. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration of carmustine with phenobarbital can increase the metabolism of carmustine, which may weaken its antitumor activity. The mechanism of interaction has not been established; however, it appears to involve induction of hepatic enzymes.
MANAGEMENT: Pharmacologic response to carmustine should be monitored more closely whenever phenobarbital is added to or withdrawn from therapy, and the dosages adjusted as necessary.
- "Product Information. BiCNU (carmustine)." Bristol-Myers Squibb, Princeton, NJ.
Generic Name: phenobarbital
Brand name: Solfoton, Luminal
Synonyms: Phenobarbital, PHENobarbital
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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