Glipizide and Ranitidine Hydrochloride
Determining the interaction of Glipizide and Ranitidine Hydrochloride and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using raNITIdine together with glipiZIDE can increase the effects of glipiZIDE, which may cause your blood sugar to get too low. Talk with your doctor before using these medications together. You may need a dose adjustment and you may need to check your blood sugar more often. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: H2 antagonists such as cimetidine and ranitidine may increase plasma concentrations of sulfonylureas and enhance hypoglycemic effects. The mechanism may be related to inhibition of liver cytochrome P450 enzymes responsible for sulfonylurea metabolism or increased absorption due to altered gastric pH. Cimetidine may also inhibit glucose metabolism. Other H2 antagonists may interact in a similar manner, particularly if increased pH is involved.
MANAGEMENT: Clinical monitoring of patient response, tolerance, and glycemic control is recommended. Patients receiving this combination should be advised to regularly monitor their blood sugar, counseled on how to recognize and treat hypoglycemia (e.g., headache, dizziness, drowsiness, nausea, tremor, hunger, weakness, or palpitations) and to notify their physician if it occurs. The sulfonylurea dosage may require reduction in affected patients.
- Dey NG, Castleden CM, Ward J, et al "The effect of cimetidine on tolbutamide kinetics." Br J Clin Pharmacol 16 (1983): 438-40
- Lee K, Mize R, Lowenstein SR "Glyburide-induced hypoglycemia and ranitidine." Ann Intern Med 107 (1987): 261-2
- Kubacka RT, Antal EJ, Juhl RP "The paradoxical effect of cimetidine and ranitidine on glibenclamide pharmacokinetics and pharmacodynamics." Br J Clin Pharmacol 23 (1987): 743-51
- Feely J, Collins WCJ, Cullen CM, et al. "Potentiation of the hypoglycaemic response to glipizide in diabetic patients by histamine H2-receptor antagonists." Br J Clin Pharmacol 35 (1993): 321-3
Generic Name: glipizide
Brand name: Glucotrol, Glucotrol XL, Glipizide XL
Synonyms: GlipiZIDE
Generic Name: ranitidine
Brand name: Zantac
Synonyms: Ranitidine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Glipizide-Ranitidine Injection
- Glipizide-Ranitidine Suspension
- Glipizide-Ranitidine Syrup
- Glipizide-Ranitidine Tablets
- Glipizide-Ranitidine Tablets and Capsules
- Glipizide-Ranolazine
- Ranitidine Hydrochloride-Glipizide and metformin
- Ranitidine Hydrochloride-Glipizide ER
- Ranitidine Hydrochloride-Glipizide Extended-Release Tablets
- Ranitidine Hydrochloride-Glipizide Tablets
- Ranitidine Hydrochloride-Glipizide XL
- Ranitidine Hydrochloride-Glofil-125