Glipizide XL and Noxafil (Posaconazole Delayed-Release Tablets)
Determining the interaction of Glipizide XL and Noxafil (Posaconazole Delayed-Release Tablets) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Posaconazole may increase the blood levels and effects of glipiZIDE. This can increase the risk of hypoglycemia (low blood sugar). Symptoms include headache, dizziness, drowsiness, nervousness, weakness, tremor, nausea, hunger, sweating, and fast or pounding heartbeats. You may need a dose adjustment or more frequent monitoring of your blood sugar to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with posaconazole may potentiate the hypoglycemic effect of glipizide. The mechanism of interaction is unknown. Posaconazole is not an inhibitor of CYP450 2C9, the isoenzyme responsible for the metabolic clearance of most sulfonylureas including glipizide. In pharmacokinetic studies, posaconazole did not significantly affect the plasma concentrations of single-dose glipizide or tolbutamide. However, glucose concentrations decreased in some subjects given glipizide and posaconazole.
MANAGEMENT: Caution is advised if glipizide is used in combination with posaconazole. Blood glucose should be closely monitored, and the glipizide dosage adjusted as necessary. Patients should also be apprised of the increased risk of hypoglycemia and be alert to potential signs and symptoms such as headache, dizziness, drowsiness, nervousness, confusion, tremor, hunger, weakness, perspiration, and palpitations.
- "Product Information. Noxafil (posaconazole)." Schering-Plough Corporation, Kenilworth, NJ.
- Wexler D, Courtney R, Richards W, Banfield C, Lim J, Laughlin M "Effect of posaconazole on cytochrome P450 enzymes: a randomized, open-label, two-way crossover study." Eur J Pharm Sci 21 (2004): 645-53
Generic Name: glipizide
Brand name: Glucotrol, Glucotrol XL, Glipizide XL
Synonyms: n.a.
Generic Name: posaconazole
Brand name: Noxafil
Synonyms: Noxafil
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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- Glipizide XL-Noxafil (Posaconazole Oral Suspension)
- Glipizide XL-Noxafil Intravenous
- Glipizide XL-Noxifol-D
- Glipizide XL-Noxivent
- Glipizide XL-NP Thyroid
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- Noxafil (Posaconazole Delayed-Release Tablets)-Gloperba
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- Noxafil (Posaconazole Delayed-Release Tablets)-Glucagen
- Noxafil (Posaconazole Delayed-Release Tablets)-GlucaGen Diagnostic
- Noxafil (Posaconazole Delayed-Release Tablets)-Glucagen Diagnostic Kit