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Glucotrol XL and Posaconazole

Determining the interaction of Glucotrol XL and Posaconazole and the possibility of their joint administration.

Check result:

Glucotrol XL <> Posaconazole

Relevance: 20.11.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Posaconazole may increase the blood levels and effects of glipiZIDE. This can increase the risk of hypoglycemia (low blood sugar). Symptoms include headache, dizziness, drowsiness, nervousness, weakness, tremor, nausea, hunger, sweating, and fast or pounding heartbeats. You may need a dose adjustment or more frequent monitoring of your blood sugar to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with posaconazole may potentiate the hypoglycemic effect of glipizide. The mechanism of interaction is unknown. Posaconazole is not an inhibitor of CYP450 2C9, the isoenzyme responsible for the metabolic clearance of most sulfonylureas including glipizide. In pharmacokinetic studies, posaconazole did not significantly affect the plasma concentrations of single-dose glipizide or tolbutamide. However, glucose concentrations decreased in some subjects given glipizide and posaconazole.

MANAGEMENT: Caution is advised if glipizide is used in combination with posaconazole. Blood glucose should be closely monitored, and the glipizide dosage adjusted as necessary. Patients should also be apprised of the increased risk of hypoglycemia and be alert to potential signs and symptoms such as headache, dizziness, drowsiness, nervousness, confusion, tremor, hunger, weakness, perspiration, and palpitations.

References

"Product Information. Noxafil (posaconazole)." Schering-Plough Corporation, Kenilworth, NJ.
Wexler D, Courtney R, Richards W, Banfield C, Lim J, Laughlin M "Effect of posaconazole on cytochrome P450 enzymes: a randomized, open-label, two-way crossover study." Eur J Pharm Sci 21 (2004): 645-53

Glucotrol XL

Generic Name: glipizide

Brand name: Glucotrol XL, Glucotrol, Glipizide XL

Synonyms: n.a.

What is Glucotrol XL?

Posaconazole

Generic Name: posaconazole

Brand name: Noxafil

Synonyms: Posaconazole (oral/injection)

What is Posaconazole?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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