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Glycerol phenylbutyrate and Palcaps

Determining the interaction of Glycerol phenylbutyrate and Palcaps and the possibility of their joint administration.

Check result:

Glycerol phenylbutyrate <> Palcaps

Relevance: 01.01.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Pancrelipase may increase the blood levels and effects of glycerol phenylbutyrate. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Concomitant use of glycerol phenylbutyrate with pancreatic enzyme replacement therapies containing lipase may increase the amount of phenylbutyrate available for absorption as well as the amount of its active metabolite, phenylacetic acid (PAA), available in the circulation. Increased levels of PAA may increase the risk of adverse events such as neurotoxicity. However, clinical data are not available.

MANAGEMENT: Caution and close monitoring of ammonia levels is recommended if glycerol phenylbutyrate is to be administered with pancreatic enzyme replacement therapies containing lipase. The dose of glycerol phenylbutyrate should be adjusted as necessary per local guidelines.

References

"Product Information. Ravicti (glycerol phenylbutyrate)." Hyperion Therapeutics Inc, South San Francisco, CA.
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Glycerol phenylbutyrate

Generic Name: glycerol phenylbutyrate

Brand name: Ravicti

Synonyms: n.a.

What is Glycerol phenylbutyrate?

Palcaps

Generic Name: pancrelipase

Brand name: Creon, Pancreaze, Pertzye, Viokace, Zenpep, Cotazym, Viokase, Zymase, Pancrease MT 4, Pancrease MT 16, Protilase, Panase, Ku-Zyme HP, Cotazym-S, Creon 10, Creon 20, Ultrase MT 20, Protilase MT-16, Creon 5, Pancrease, Pancrease MT 10, Vio-Moore, Panokase, Ilozyme, Pancrease MT 20, Ultrase, Ultrase MT 12, Pancron D/R, Encron-10, Ultrase MT 18, Arco-Lase, Lipram, Pancrecarb MS-8, Pancrecarb MS-4, Lipram-UL 18, Lipram-CR20, Lipram-UL 12, Lipram-UL 20, Viokase 16, Pancreatil-UL 12, Pangestyme CN 10, Pangestyme CN 20, Pangestyme MT 16, Pangestyme UL 18, Pangestyme EC, Kutrase, Ku-Zyme, Lipram-CR, Plaretase, Viokase 8, Lipram-CR5, Lapase, Dygase, Pancrecarb MS-16, Pangestyme UL 20, Panocaps, Panocaps MT 16, Lipram-CR10, Palcaps 10, Lipram-PN10, Lipram-PN16, Lipram-PN20, Panokase 16, Ultresa

Synonyms: Pancrelipase

What is Palcaps?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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