Glycerol phenylbutyrate and Trabectedin

• Generic Name: glycerol phenylbutyrate
• Dosage Forms: n.a.
• Other Brand Names: Ravicti

Glycerol phenylbutyrate binds with other substances in the liver and kidneys to help eliminate nitrogen from the body. Excess nitrogen can cause hyperammonemia (HYE-per-AM-moe-NEE-mee-a), a build-up of ammonia in the blood. Ammonia is very toxic when it circulates in blood and tissues and can cause permanent brain damage, coma, or death.

Glycerol phenylbutyrate helps prevent a build-up of ammonia in the blood in people with urea cycle disorder. glycerol phenylbutyrate is used in adults and children who are at least 2 months old. Glycerol phenylbutyrate will not treat hyperammonemia.

Glycerol phenylbutyrate is usually given together with a low-protein diet and sometimes dietary supplements.

Glycerol phenylbutyrate may also be used for purposes not listed in this medication guide.

• Generic Name: trabectedin
• Dosage Forms: n.a.
• Other Brand Names: Yondelis

Trabectedin is a cancer medicine that interferes with the growth and spread of cancer cells in the body.

Trabectedin is used to treat liposarcoma, a rare type of cancer that grows in fatty tissues of the body.

Trabectedin is also used to treat leiomyosarcoma, a rare fast-growing type of cancer that grows in many tissues of the body, including fat, muscle, bone, joints, and blood vessels.

Trabectedin is used to treat cancer that has spread to other parts of the body or cannot be treated with surgery.

Trabectedin may also be used for purposes not listed in this medication guide.