Glycerol phenylbutyrate and Uptravi

• Generic Name: glycerol phenylbutyrate
• Dosage Forms: n.a.
• Other Brand Names: Ravicti

Glycerol phenylbutyrate binds with other substances in the liver and kidneys to help eliminate nitrogen from the body. Excess nitrogen can cause hyperammonemia (HYE-per-AM-moe-NEE-mee-a), a build-up of ammonia in the blood. Ammonia is very toxic when it circulates in blood and tissues and can cause permanent brain damage, coma, or death.

Glycerol phenylbutyrate helps prevent a build-up of ammonia in the blood in people with urea cycle disorder. glycerol phenylbutyrate is used in adults and children who are at least 2 months old. Glycerol phenylbutyrate will not treat hyperammonemia.

Glycerol phenylbutyrate is usually given together with a low-protein diet and sometimes dietary supplements.

Glycerol phenylbutyrate may also be used for purposes not listed in this medication guide.

• Generic Name: selexipag
• Dosage Forms: tablet, coated
• Other Brand Names: Uptravi, Uptravi Titration Pack

Uptravi (selexipag) lowers blood pressure in your lungs by dilating (widening) blood vessels that supply blood to the lungs.

Uptravi is used to treat pulmonary arterial hypertension (PAH).

Uptravi helps keep your condition from getting worse and helps lower your risk of needing to be hospitalized for PAH.