Glycerol phenylbutyrate and Xenical

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Orlistat may decrease the blood levels of glycerol phenylbutyrate, which may make the medication less effective in treating your condition. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Concomitant use of glycerol phenylbutyrate with medicines known to inhibit pancreatic lipases may theoretically lead to reduced intestinal absorption of its active moiety phenylbutyrate, and hence reduced control of plasma ammonia levels. After oral ingestion, pancreatic lipases hydrolyse glycerol phenylbutyrate in the small intestine to glycerol and phenylbutyrate, allowing the absorption of phenylbutyrate and its subsequent conversion to the active metabolite, phenylacetic acid, by beta-oxidation. Clinical data are not available.

MANAGEMENT: Caution and close monitoring of ammonia levels is recommended if glycerol phenylbutyrate is to be administered with a gastrointestinal lipase inhibitor such as orlistat. The dose of glycerol phenylbutyrate should be adjusted as necessary per local guidelines.

Glycerol phenylbutyrate

Generic Name: glycerol phenylbutyrate

Brand name: Ravicti

Synonyms: n.a.

What is Glycerol phenylbutyrate?

Xenical

Generic Name: orlistat

Brand name: Alli, Xenical, Alli

Synonyms: n.a.

What is Xenical?