GNP Cold Relief Plus and Leader Acid Control
Determining the interaction of GNP Cold Relief Plus and Leader Acid Control and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Animal studies have suggested that ranitidine may potentiate the hepatotoxicity of acetaminophen, however, a double-blind placebo-controlled crossover study has failed to confirm this finding in humans. Acetaminophen dosage adjustments are not indicated.
- Rogers SA, Gale KC, Newton JF, et al "Inhibition by ranitidine of acetaminophen conjugation and its possible role in ranitidine potentiation of acetaminophen-induced hepatotoxicity." J Pharmacol Exp Ther 245 (1988): 887-94
- Jack D, Thomas M, Skidmore IF "Ranitidine and paracetamol metabolism." Lancet 2 (1985): 1067
Generic Name: acetaminophen / chlorpheniramine / phenylephrine
Brand name: Cold Relief Plus, EQL Effervescent Plus Cold, GNP Cold Relief Plus, QC Cold Relief Plus, Alka-Seltzer Plus Cold, Comtrex Severe Cold & Sinus, Contac Cold+Flu Maximum Strength, Dristan Cold Multi Symptom Formula, Robitussin Nighttime Nasal Relief, Tylenol Allergy Multi-Symptom, Tylenol Children's Plus Cold, Tylenol Sinus Congestion Nighttime, Contac Cold/Flu Day & Night, Coricidin D Cold/Flu/Sinus, Dristan Cold, Medicidin-D, Onset Forte, Robitussin Peak Cold Nasal Relief, Super Cold Tabs, Super Strength Sinadrin, Tylenol Sinus Congestion/Pain
Synonyms: n.a.
Generic Name: ranitidine
Brand name: Zantac
Synonyms: Ranitidine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- GNP Cold Relief Plus-Leader Acid Reducer Maximum Strength
- GNP Cold Relief Plus-Leader All Day Allergy
- GNP Cold Relief Plus-Leader Allergy D 12
- GNP Cold Relief Plus-Leader Allergy Relief
- GNP Cold Relief Plus-Leader Allergy Relief D-24
- GNP Cold Relief Plus-Leader Allerhist
- Leader Acid Control-GNP Day Time D Cold/Flu
- Leader Acid Control-GNP Mercuroclear
- Leader Acid Control-GNP Pre-Menstrual Relief Max Strength
- Leader Acid Control-GNP Tussin Night Time
- Leader Acid Control-Gocovri
- Leader Acid Control-Gold Sodium Thiomalate