Gold Sodium Thiomalate and Prestalia

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using perindopril together with an injection of gold sodium thiomalate can cause facial flushing, nausea, vomiting, and low blood pressure. Elderly patients may be particularly prone to these effects. Contact your doctor if your condition worsens. You may need a dose adjustment or special tests to use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor

MONITOR: Concomitant ACE inhibitor therapy may potentiate the risk of nitritoid (vasomotor) reactions associated with injectable gold therapy. The mechanism of interaction is unknown, although investigators suggest that ACE inhibitors may unmask drug hypersensitivity reactions by preventing the breakdown of bradykinins. In one published case report, two patients with rheumatoid arthritis who had been treated with intramuscular sodium aurothiomalate for over 20 years without incident developed nitritoid reactions after they were started on ACE inhibitor therapy within the previous 15 months. The interaction was also suspected in several other reported cases. One patient experienced anaphylaxis and cardiac arrest after a gold injection. She had been on gold therapy for 16 months and lisinopril for 12 months. Two other cases occurred 1 to 4 weeks after starting ACE inhibitor therapy. The patients were switched to gold sodium aurothioglucose with no further problems. In general, nitritoid reactions can occur in approximately 5% of patients treated with gold. Most are transient and occur within a few minutes of drug administration within the first year of treatment. Serious sequelae including myocardial infarction have been reported.

MANAGEMENT: Patients on injectable gold therapy in combination with an ACE inhibitor should be monitored for symptoms of nitritoid reactions such as facial flushing, nausea, vomiting, and hypotension following an injection. Elderly patients in particular should be observed following treatment. Oxygen, intravenous fluids, epinephrine, steroids, and other supportive therapy may be necessary for treatment.

Gold Sodium Thiomalate

Generic Name: gold sodium thiomalate

Brand name:

Synonyms: n.a.

What is Gold Sodium Thiomalate?

Prestalia

Generic Name: amlodipine / perindopril

Brand name: Prestalia

Synonyms: n.a.

What is Prestalia?