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Gonitro and Oxycodone and naloxone

Determining the interaction of Gonitro and Oxycodone and naloxone and the possibility of their joint administration.

Check result:

Gonitro <> Oxycodone and naloxone

Relevance: 05.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

The following interaction applies only if you are using naloxone in an injectable formulation: naloxone can reverse the effects of oxyCODONE. If you are a physically dependent patient you may experience withdrawal symptoms. This can cause nausea, vomiting, diarrhea, aches, fever, runny nose, sneezing, nervousness, irritability, shivering, and abdominal cramps. Talk to your doctor if you have any questions or concerns. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: This warning does not apply to the naloxone component in non-injectable formulations of naloxone-containing combination medicines. Naloxone injection is an antagonist that will reverse the actions of opiates. This reversal can occur when the opiate drug is being used clinically and when it is being abused. Physically dependent patients may experience withdrawal symptoms. Abrupt postoperative opioid reversal has resulted in hypotension, ventricular tachycardia and fibrillation, pulmonary edema, cardiac arrest, encephalopathy, and death.

MANAGEMENT: Patients receiving naloxone injection should be monitored for changes in vital signs, nausea, vomiting, diarrhea, aches, fever, runny nose, sneezing, nervousness, irritability, shivering, abdominal cramps.

References

Cerner Multum, Inc. "Australian Product Information." O 0
Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
"Product Information. Narcan (naloxone)." DuPont Pharmaceuticals, Wilmington, DE.

Gonitro

Generic Name: nitroglycerin

Brand name: Gonitro, Gonitro, Nitrolingual, NitroMist, Nitrostat, Nitro-Time, Minitran, Nitro TD Patch-A, Nitro-Dur, Nitro-Bid, Nitrol Appli-Kit, Rectiv

Synonyms: GoNitro

What is Gonitro?

Oxycodone and naloxone

Generic Name: naloxone / oxycodone

Brand name: Targiniq ER

Synonyms: Oxycodone and naloxone (Oral)

What is Oxycodone and naloxone?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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