Good Neighbor Acid Control and Propulsid (Cisapride Suspension)
Determining the interaction of Good Neighbor Acid Control and Propulsid (Cisapride Suspension) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:During coadministration, cisapride may accelerate but slightly decrease the extent of gastrointestinal absorption of ranitidine. These effects are thought to be secondary to the increased gastrointestinal transit induced by cisapride. In twelve healthy volunteers given cisapride (10 mg single dose) and ranitidine (150 mg single dose), median time to reach peak plasma concentration (Tmax) of ranitidine was one hour less than when ranitidine was taken alone, and area under the concentration-time curve (AUC) was decreased by 24%. Theoretically, the reduced Tmax may translate to a quicker onset of action of ranitidine. The reduction in bioavailability is unlikely to be of clinical significance during regular administration, although the duration of action of a single dose of oral ranitidine may be shortened.
- Rowbotham DJ, Milligan K, McHugh P "Effect of single doses of cisapride and ranitidine administered simultaneously on plasma concentrations of cisapride and ranitidine." Br J Anaesth 67 (1991): 302-5
Generic Name: ranitidine
Brand name: Zantac
Synonyms: Ranitidine
Generic Name: cisapride
Brand name: Propulsid
Synonyms: Propulsid (Suspension), Propulsid
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Good Neighbor Acid Control-Propulsid (Cisapride Tablets)
- Good Neighbor Acid Control-Propylhexedrine
- Good Neighbor Acid Control-Propylthiouracil
- Good Neighbor Acid Control-ProQuad
- Good Neighbor Acid Control-Proquin XR
- Good Neighbor Acid Control-Prorex
- Propulsid (Cisapride Suspension)-Good Neighbor Acid Reducer
- Propulsid (Cisapride Suspension)-Good Neighbor All Day Allergy D
- Propulsid (Cisapride Suspension)-Good Neighbor All Day Pain Relief
- Propulsid (Cisapride Suspension)-Good Neighbor Allergy Relief
- Propulsid (Cisapride Suspension)-Good Neighbor Anti-Diarrheal
- Propulsid (Cisapride Suspension)-Good Neighbor Childrens Ibuprofen