Goserelin Acetate and Thalitone

• Generic Name: goserelin
• Dosage Forms: n.a.
• Other Brand Names: Zoladex

Palliative treatment of advanced prostate cancer. Considered one of several first-line options for hormonal therapy; other options include orchiectomy, estrogens, and antiandrogens.

In clinical studies, goserelin (3.6 mg every 4 weeks) was as effective as orchiectomy. Clinical outcome in patients receiving goserelin 10.8 mg every 12 weeks expected to be similar to that of patients receiving goserelin 3.6 mg every 4 weeks.

Also used as an adjunct to radiation therapy in patients with stage III[C]) prostate cancer.

Treatment of locally confined stage T2b-T4 (B2-C) prostate cancer in conjunction with flutamide and radiation therapy.

Palliative treatment of endometriosis. Experience with goserelin has been limited to women ≥18 years of age who received consecutive therapy (3.6 mg every 4 weeks) for 6 months.

Palliative treatment of advanced breast cancer in premenopausal and perimenopausal women.

Used as an endometrial-thinning agent prior to endometrial ablation procedures for the treatment of dysfunctional uterine bleeding.

• Generic Name: chlorthalidone
• Dosage Forms: tablet
• Other Brand Names:

  Hygroton, Thalitone

Chlorthalidone is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Chlorthalidone is also used to treat fluid retention (edema) that is caused by congestive heart failure, severe liver disease (cirrhosis), kidney disease, or treatment with a hormone or steroid medicine.

Chlorthalidone is a diuretic (water pill). It reduces the amount of water in the body by increasing the flow of urine, which helps to lower blood pressure.

Chlorthalidone is available only with your doctor's prescription.