Granisetron Hydrochloride and M-M-R II Vaccine

• Generic Name: granisetron
• Dosage Forms: n.a.
• Other Brand Names: Kytril, Sustol, Sancuso

Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy, including high-dose cisplatin.

For prevention of nausea and vomiting associated with highly emetogenic chemotherapy regimens (including an anthracycline plus cyclophosphamide), ASCO recommends a 3-drug antiemetic regimen consisting of an NK1 receptor antagonist (e.g., either oral aprepitant or IV fosaprepitant), a 5-HT3 receptor antagonist (e.g., dolasetron, granisetron, ondansetron, palonosetron), and dexamethasone. ASCO states that fixed-combination netupitant and palonosetron plus dexamethasone is an additional treatment option.

For moderately emetogenic chemotherapy regimens, ASCO recommends a 2-drug antiemetic regimen preferably consisting of palonosetron and dexamethasone. If palonosetron is not available, a first-generation 5-HT3 receptor antagonist (preferably granisetron or ondansetron) may be substituted. Limited evidence suggests that aprepitant may be added to this regimen; in such cases, use of any 5-HT3 receptor antagonist is appropriate.

For chemotherapy regimens with a low emetogenic risk, ASCO recommends administration of a single dose of dexamethasone prior to chemotherapy.

For chemotherapy regimens with minimal emetogenic risk, ASCO states that routine antiemetic administration is not necessary.

Prevention and treatment of postoperative nausea and vomiting.

Routine prophylaxis not recommended in patients in whom there is little expectation that nausea and/or vomiting will occur postoperatively.

Recommended for patients who, in the clinician’s judgment, must avoid nausea and/or vomiting postoperatively, even when anticipated incidence is low.

Prevention of nausea and vomiting associated with radiation, including total body irradiation and daily fractionated abdominal radiation.

• Generic Name: measles virus vaccine / mumps virus vaccine / rubella virus vaccine
• Dosage Forms: injection, powder, lyophilized, for suspension
• Other Brand Names: M-M-R II

Measles, mumps, and rubella are serious diseases caused by viruses spread from person to person through the air. Measles, mumps, and rubella can cause minor symptoms such as fever, headache, sore throat, cough, swollen glands, runny nose, eye irritation, skin rash, muscle aches, and joint pain.

More serious symptoms of measles or mumps include pneumonia, hearing loss, painful swelling of the testicles or ovaries, and rarely permanent brain damage or death.

Becoming infected with rubella virus (also called German Measles) during pregnancy can result in a miscarriage or serious birth defects.

The measles, mumps, and rubella (MMR) vaccine is used to help prevent these diseases by causing your body to develop immunity to the disease. This vaccine will not treat an active infection that has already developed in the body.

MMR vaccine is for use in children between the ages of 12 months and 6 years old, and in adults who have never received the vaccine or had the diseases.

Like any vaccine, the MMR vaccine may not provide protection from disease in every person.