Gris-PEG and Victrelis

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Griseofulvin may reduce the blood levels and effects of boceprevir, which may reduce its effectiveness in treating hepatitis C. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of the hepatitis C virus (HCV) NS3/4A protease inhibitors, boceprevir and telaprevir, which are metabolized by the isoenzyme. In 16 study subjects, administration of a single 750 mg dose of telaprevir during treatment with the potent CYP450 3A4 inducer rifampin (600 mg daily for 7 days) reduced the telaprevir peak plasma concentration (Cmax) and systemic exposure (AUC) by an average of 86% and 92%, respectively, compared to administration alone. No data are available for boceprevir; however, a similar interaction is expected.

MANAGEMENT: Caution is recommended if boceprevir or telaprevir is used in combination with a CYP450 3A4 inducer. Close clinical monitoring of the virologic response to the HCV NS3/4A protease inhibitor is recommended.

Gris-PEG

Generic Name: griseofulvin

Brand name: Gris-PEG, Grifulvin V, Fulvicin P/G, Fulvicin U/F, Grisactin Ultra, Grisactin 250, Grisactin 500, Griseofulicin, Griseofulvic

Synonyms: n.a.

What is Gris-PEG?

Victrelis

Generic Name: boceprevir

Brand name: Victrelis

Synonyms: n.a.

What is Victrelis?