Griseofulvin and Ketoconazole (Systemic)

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using griseofulvin together with ketoconazole may increase the risk of hepatitis, or inflammation of the liver. If you are currently receiving or have recently received griseofulvin, some experts recommend waiting at least a month before starting treatment with ketoconazole. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. You should avoid or limit the use of alcohol while being treated with these medications. Call your doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of hepatitis. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: The concomitant or sequential use of griseofulvin and ketoconazole may increase the risk of hepatitis. An apparent association has been reported between recent treatment with griseofulvin and hepatotoxicity associated with ketoconazole.

MANAGEMENT: It is recommended that treatment with ketoconazole should not be initiated until at least one month after discontinuation of griseofulvin.

Griseofulvin

Generic Name: griseofulvin

Brand name: Grifulvin V, Fulvicin P/G, Fulvicin U/F, Gris-PEG, Grisactin Ultra, Grisactin 250, Grisactin 500, Griseofulicin, Griseofulvic

Synonyms: n.a.

What is Griseofulvin?

Ketoconazole (Systemic)

Generic Name: ketoconazole

Brand name: Nizoral

Synonyms: Ketoconazole

What is Ketoconazole (Systemic)?