About us Contacts Drug interactions: 390 212
Drug search by name

Griseofulvin Microsize Oral Suspension and Provigil

Determining the interaction of Griseofulvin Microsize Oral Suspension and Provigil and the possibility of their joint administration.

Check result:
Griseofulvin Microsize Oral Suspension <> Provigil
Relevance: 14.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Griseofulvin may reduce the blood levels of modafinil, which may make the medication less effective in some cases. Contact your doctor if your symptoms worsen or your condition changes. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of modafinil (the racemate) and armodafinil (the R-enantiomer), which are both partially metabolized by the isoenzyme.

MANAGEMENT: Pharmacologic response to modafinil or armodafinil should be monitored more closely whenever a CYP450 3A4 inducer is added to or withdrawn from therapy. Dose adjustments may be required if an interaction is suspected.

References
  • "Product Information. Nuvigil (armodafinil)." Cephalon Inc, West Chester, PA.
  • "Product Information. Provigil (modafinil)." Cephalon, Inc, West Chester, PA.
Griseofulvin Microsize Oral Suspension

Generic Name: griseofulvin

Brand name: Grifulvin V, Fulvicin P/G, Fulvicin U/F, Gris-PEG, Grisactin Ultra, Grisactin 250, Grisactin 500, Griseofulicin, Griseofulvic

Synonyms: Griseofulvin

Provigil

Generic Name: modafinil

Brand name: Provigil

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.