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Guaifenex and Tivorbex

Determining the interaction of Guaifenex and Tivorbex and the possibility of their joint administration.

Check result:

Guaifenex <> Tivorbex

Relevance: 28.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using indomethacin together with phenylpropanolamine may increase your blood pressure. Contact your doctor if you experience increased side effects or if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or your blood pressure monitored to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: The concurrent administration of indomethacin and phenylpropanolamine was associated with severe hypertension in one reported case. The mechanism is unknown but may be related to inhibition of prostaglandin synthesis resulting in higher sensitivity to sympathomimetic-induced blood pressure increases. This interaction was not demonstrated in a study with normotensive subjects.

MANAGEMENT: Until more information is available, close monitoring of blood pressure is recommended.

References

Lee KY, Vandongen R, Beilin LJ "Severe hypertension after ingestion of an appetite suppressant (phenylpropanolamine) with indomethacin." Lancet 1 (1979): 1110-1

Guaifenex

Generic Name: guaifenesin / phenylephrine / phenylpropanolamine

Brand name: Ami-Tex, Banex, Dura-Gest, Duratex, Enomine, Entex, Fentex, Guaifenex, Phenylfenesin, Quintex

Synonyms: n.a.

What is Guaifenex?

Tivorbex

Generic Name: indomethacin

Brand name: Indocin, Indocin SR, Tivorbex

Synonyms: n.a.

What is Tivorbex?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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