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Guanethidine and Haloperidol Intramuscular

Determining the interaction of Guanethidine and Haloperidol Intramuscular and the possibility of their joint administration.

Check result:

Guanethidine <> Haloperidol Intramuscular

Relevance: 27.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using haloperidol together with guanethidine may decrease the effects of guanethidine. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or need your blood pressure checked more often to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Haloperidol may decrease the antihypertensive effect of some peripherally acting antiadrenergic agents. The mechanism is competition for adrenergic neurons. Hypotension may occur if haloperidol is discontinued from the regimen.

MANAGEMENT: Blood pressure monitoring is recommended during concurrent use and after discontinuation of haloperidol. An alternative antihypertensive or antipsychotic agent may be considered if evidence of an interaction is observed.

References

Markowitz JS, Wells BG, Carson WH "Interactions between antipsychotic and antihypertensive drugs." Ann Pharmacother 29 (1995): 603-9
Janowsky DS, El-Yousef MK, Davis JM, Fann WE "Antagonism of guanethidine by chlorpromazine." Am J Psychiatry 130 (1973): 808-12

Guanethidine

Generic Name: guanethidine

Brand name:

Synonyms: Guanethidine (Oral)

What is Guanethidine?

Haloperidol Intramuscular

Generic Name: haloperidol

Brand name: Haldol, Haldol Decanoate

Synonyms: Haloperidol

What is Haloperidol Intramuscular?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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