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Guanethidine and Silenor

Determining the interaction of Guanethidine and Silenor and the possibility of their joint administration.

Check result:

Guanethidine <> Silenor

Relevance: 27.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using doxepin together with guanethidine. Taking these medicaions together can make guanethidine less effective. You may need a dose adjustment or need your blood pressure checked more often if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Tricyclic antidepressants (TCAs) may reduce the antihypertensive effects of guanethidine. Loss of blood pressure control may result. The mechanism is TCA-induced inhibition of guanethidine uptake into adrenergic neurons. Hypotensive reactions may occur when the tricyclic antidepressant is discontinued. Other adrenergic neurone blockers may also be affected.

MANAGEMENT: Either a different antidepressant or a different antihypertensive agent (such as an ACE inhibitor or beta-blocker) should be considered. If patients do receive this combination, their blood pressure should be closely monitored when initiating or discontinuing either drug.

References

Gokhale SD, Gulati OD, Udwadia BP "Antagonism of the adrenergic neurone blocking action of guanethidine by certain antidepressant and antihistamine drugs." Arch Int Pharmacodyn Ther 160 (1966): 321-9
MacLennan WJ "Drug interactions." Gerontol Clin (Basel) 16 (1974): 18-24
Stone CA, Porter CC, Stavorski JM, et al "Antagonism of certain effects of catecholamine-depleting agents by antidepressant and related drugs." J Pharmacol Exp Ther 144 (1964): 196-204
Leishman AW, Matthews HL, Smith AJ "Antagonism of guanethidine by imipramine." Lancet 1 (1963): 112
Ober KF, Wang RI "Drug interactions with guanethidine." Clin Pharmacol Ther 14 (1973): 190-5
Poe TE, Edwards JL, Taylor RB "Hypertensive crisis possibly due to drug interaction." Postgrad Med 66 (1979): 235-7
Meyer JF, McAllister CK, Goldberg LI "Insidious and prolonged antagonism of guanethidine by amitriptyline." JAMA 213 (1970): 1487-8
Koe BK, Constantine JW "Blocking H 3 -norepinephrine uptake and some guanethidine-induced effects with tricyclic psychotherapeutic drugs." Arch Int Pharmacodyn Ther 195 (1972): 71-80
Mitchell JR, Cavanaugh JH, Arias L, Oates JA "Guanethidine and related agents. III: antagonism by drugs which inhibit the norepinephrine pump in man." J Clin Invest 49 (1970): 1596-604

Guanethidine

Generic Name: guanethidine

Brand name:

Synonyms: Guanethidine (Oral)

What is Guanethidine?

Silenor

Generic Name: doxepin

Brand name: Silenor, Sinequan, Sinequan

Synonyms: n.a.

What is Silenor?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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