Guanethidine and Sinemet 25-250
Determining the interaction of Guanethidine and Sinemet 25-250 and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Limited data from two patients suggest that the antihypertensive effects of guanethidine are enhanced by the addition of levodopa. The mechanism is unknown. Because of the paucity of data, it is not clear if an interaction exists. If guanethidine and levodopa are used concomitantly, monitoring of blood pressure is recommended, especially orthostatic measurements. Also, the clinician should be aware that if levodopa is discontinued, the antihypertensive effects of guanethidine could be decreased.
- Hunter KR, Stern GM, Laurence DR "Use of levodopa with other drugs." Lancet 2 (1970): 1283-5
Generic Name: guanethidine
Brand name:
Synonyms: Guanethidine (Oral)
Generic Name: carbidopa / levodopa
Brand name: Parcopa, Rytary, Sinemet, Sinemet CR, Duopa
Synonyms: Carbidopa and levodopa, Carbidopa and Levodopa
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Guanethidine-Sinemet 250/25
- Guanethidine-Sinemet CR
- Guanethidine-Sinemet CR 100/25
- Guanethidine-Sinemet CR 200/50
- Guanethidine-Sinequan
- Guanethidine-Sinequan (Doxepin Capsules)
- Sinemet 25-250-Guanfacine
- Sinemet 25-250-Guanfacine ER
- Sinemet 25-250-Guanfacine Extended-Release Tablets
- Sinemet 25-250-Guanfacine Tablets
- Sinemet 25-250-Guanidine
- Sinemet 25-250-Guar Gum