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Guanfacine and Wellbutrin XL

Determining the interaction of Guanfacine and Wellbutrin XL and the possibility of their joint administration.

Check result:
Guanfacine <> Wellbutrin XL
Relevance: 27.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using guanFACINE together with buPROPion may add to the side effects of buPROPion. Contact your doctor if you experience seizures or other mental status changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: A case has been reported in which a 10 year old girl experienced a grand mal seizure ten days after her guanfacine dose was increased to 0.5 mg two times daily. The girl was taking bupropion 100 mg three times a day concurrently. The mechanism is unknown and causality has not been definitely determined.

MANAGEMENT: Until more information is available, patients should be monitored for increased seizure activity is recommended if these two drugs are to be administered concurrently.

References
  • Tilton P "Bupropion and guanfacine." J Am Acad Child Adolesc Psychiatry 37 (1998): 682-3
Guanfacine

Generic Name: guanfacine

Brand name: Intuniv, Tenex

Synonyms: GuanFACINE

Wellbutrin XL

Generic Name: bupropion

Brand name: Aplenzin, Buproban, Forfivo XL, Wellbutrin SR, Wellbutrin XL, Zyban, Zyban Advantage Pack, Budeprion XL

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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