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Guar Gum and Zimamox

Determining the interaction of Guar Gum and Zimamox and the possibility of their joint administration.

Check result:
Guar Gum <> Zimamox
Relevance: 01.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Talk to your doctor before using guar gum together with amoxicillin. Products containing guar gum can interfere with the absorption of amoxicillin when it is taken orally. Your doctor may be able to prescribe alternatives that do not interact, or you may need to separate the dosing times of each medication by as much as possible. Contact your doctor if your infection worsens. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Concurrent administration of guar gum may decrease the plasma levels of orally administered penicillins by reducing their absorption. In a study of 10 healthy volunteers administered phenoxymethyl penicillin with and without guar gum, both the peak serum concentration and the area under the serum concentration-time curve of penicillin were found to be significantly reduced by the gum.

MANAGEMENT: The use of guar gum should preferably be avoided during oral penicillin therapy. If these agents must be used together, separating the times of administration by as much as possible may help but has not been studied.

References
  • Huupponen R, Seppala P, Iisalo E "Effect of guar gum, a fibre preparation, on digoxin and penicillin absorption in man." Eur J Clin Pharmacol 26 (1984): 279-81
  • Fugh-Berman A "Herb-drug interactions." Lancet 355 (2000): 134-8
Guar Gum

Generic Name: guar gum

Brand name:

Synonyms: n.a.

Zimamox

Generic Name: amoxicillin

Brand name: Amoxil, Moxatag, Trimox

Synonyms: Amoxicillin

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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