Halcion and Modafinil

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using modafinil together with triazolam may decrease the effects of triazolam. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with modafinil (the racemate) or armodafinil (the R-enantiomer) may decrease the plasma concentrations and efficacy of triazolam. The mechanism involves induction of intestinal CYP450 3A4-mediated first-pass metabolism by modafinil and armodafinil, with possible secondary induction of hepatic 3A4 metabolism. In 16 healthy subjects, modafinil treatment (200 mg orally once daily for 7 days, then 400 mg for 21 days) decreased the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of triazolam (0.125 mg single dose) by 42% and 59%, respectively, relative to pretreatment values. The same parameters increased by 7% and 8%, respectively, in 18 subjects receiving placebo. Also, triazolam oral clearance (Cl/F) increased 173% in the modafinil group, while little change occurred in the placebo group.

MANAGEMENT: Pharmacologic response to triazolam should be monitored more closely whenever modafinil or armodafinil is added to or withdrawn from therapy, and the triazolam dosage adjusted as necessary.

Halcion

Generic Name: triazolam

Brand name: Halcion

Synonyms: n.a.

What is Halcion?

Modafinil

Generic Name: modafinil

Brand name: Provigil

Synonyms: n.a.

What is Modafinil?