Haldol and Methyldopate

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using haloperidol together with methyldopa may lead to increased side effects. Contact your doctor if you experience mental status changes, increased heart rate, lightheadedness, dizziness or feeling like you might pass out, especially when getting up from a sitting or lying position. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Case reports suggest that the combination of haloperidol and methyldopa may result in mental-status (dementia-type) changes. Another small study has suggested that this combination may be beneficial in the treatment of schizophrenia. The mechanism is unknown. This interaction is also theoretically possible with benperidol. In addition, neuroleptic agents may potentiate the hypotensive effect of some medications secondary to their peripheral alpha-1 adrenergic blocking activity. Orthostatic hypotension and syncope associated with vasodilation may occur, particularly during the initial dose titration period of neuroleptic therapy.

MANAGEMENT: Observation for alterations in the response to the neuroleptic agent and for extrapyramidal effects is advisable if these drugs must be used together. Close clinical monitoring for development of hypotension is also recommended. Patients should be advised to notify their physician if they experience dizziness, lightheadedness, syncope, orthostasis, or tachycardia. A lower starting dosage and slower titration of the neuroleptic agent may be appropriate in patients receiving antihypertensive therapy, especially if they are elderly.

Haldol

Generic Name: haloperidol

Brand name: Haldol, Haldol Decanoate

Synonyms: n.a.

What is Haldol?

Methyldopate

Generic Name: methyldopa

Brand name: Aldomet

Synonyms: Methyldopa

What is Methyldopate?