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Halfan and Lariam

Determining the interaction of Halfan and Lariam and the possibility of their joint administration.

Check result:

Halfan <> Lariam

Relevance: 04.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using halofantrine together with mefloquine is not recommended. Combining these medications can increase the risk of an irregular heart rhythm that may be serious. Do not take halofantrine with mefloquine or within 15 weeks of your last dose of mefloquine. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats during treatment with either of these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

CONTRAINDICATED: Coadministration of halofantrine and mefloquine may have additive prolonging effects on the QT interval. The risk of ventricular arrhythmias including ventricular tachycardia and torsade de pointes may be increased. Death has been reported with this combination.

MANAGEMENT: Halofantrine should not be administered with mefloquine or within 15 weeks of the last dose of mefloquine due to increased risk of potentially fatal prolongation of the QTc interval. The manufacturer recommends performing an ECG before initiating halofantrine therapy and monitoring cardiac rhythm during and for 8 to 12 hours after completion of therapy.

References

Nosten F, ter Kuile FO, Luxemburger C, et al "Cardiac effects of antimalarial treatment with halofantrine." Lancet 341 (1993): 1054-6
"Product Information. Lariam (mefloquine)." Roche Laboratories, Nutley, NJ.
Abernethy DR, Wesche DL, Barbey JT, et al. "Stereoselective halofantrine disposition and effect: concentration-related QTc prolongation." Br J Clin Pharmacol 51 (2001): 231-7
"Sudden death in a traveler following halofantrine administration--Togo, 2000." MMWR Morb Mortal Wkly Rep 50 (2001): 169-70, 179
"Product Information. Halfan (halofantrine)." GlaxoSmithKline, Philadelphia, PA.
Darpo B "Spectrum of drugs prolonging QT interval and the incidence of torsades de pointes." Eur Heart J Suppl 3(Suppl K) (2001): K70-80

Halfan

Generic Name: halofantrine

Brand name:

Synonyms: n.a.

What is Halfan?

Lariam

Generic Name: mefloquine

Brand name: Lariam

Synonyms: n.a.

What is Lariam?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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