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Halfan and Posaconazole

Determining the interaction of Halfan and Posaconazole and the possibility of their joint administration.

Check result:

Halfan <> Posaconazole

Relevance: 04.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using halofantrine and posaconazole is not recommended. Taking these drugs together can affect the rhythm of your heart. Call your doctor if you have symptoms of irregular heartbeat, chest tightness, blurred vision or nausea. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

CONTRAINDICATED: Coadministration with posaconazole may increase the plasma concentrations of halofantrine, resulting in an increased risk of QT interval prolongation and ventricular arrhythmias including torsade de pointes. The mechanism is posaconazole inhibition of CYP450 3A4, the isoenzyme responsible for the metabolic clearance of halofantrine. Halofantrine has been associated with QT interval prolongation, ventricular arrhythmias, and sudden death, even at recommended dosages.

MANAGEMENT: The use of halofantrine in combination with posaconazole is considered contraindicated.

References

Baune B, Flinois JP, Furlan V, et al. "Halofantrine metabolism in microsomes in man: major role of CYP 3A4 and CYP 3A5." J Pharm Pharmacol 51 (1999): 419-26
Abernethy DR, Wesche DL, Barbey JT, et al. "Stereoselective halofantrine disposition and effect: concentration-related QTc prolongation." Br J Clin Pharmacol 51 (2001): 231-7
"Product Information. Halfan (halofantrine)." GlaxoSmithKline, Philadelphia, PA.
"Product Information. Noxafil (posaconazole)." Schering-Plough Corporation, Kenilworth, NJ.

Halfan

Generic Name: halofantrine

Brand name:

Synonyms: n.a.

What is Halfan?

Posaconazole

Generic Name: posaconazole

Brand name: Noxafil

Synonyms: Posaconazole (oral/injection)

What is Posaconazole?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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