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Haloperidol and Rasuvo

Determining the interaction of Haloperidol and Rasuvo and the possibility of their joint administration.

Check result:

Haloperidol <> Rasuvo

Relevance: 16.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

In an isolated case report, a man whose psoriasis had been well controlled on methotrexate for ten months developed pellagra-like photosensitive dermatitis two weeks following the addition of haloperidol. A possible interaction between methotrexate and haloperidol, combined with a deficiency of niacin, riboflavin and other water-soluble vitamins, was considered. The condition resolved within 5 days after discontinuation of haloperidol and initiation of multivitamin supplements, but reactivation occurred less than 24 hours after the next dose of methotrexate was given, probably due to photosensitivity recall phenomenon, which is an important but rarely encountered adverse effect of methotrexate. Treatment was stopped, and within one week, the dermatitis resolved. Methotrexate was restarted two weeks later without incident.

References

Thami GP, Kaur S, Kanwar AJ "Delayed reactivation of haloperidol induced photosensitive dermatitis by methotrexate." Postgrad Med J 78 (2002): 116-7

Haloperidol

Generic Name: haloperidol

Brand name: Haldol, Haldol Decanoate

Synonyms: n.a.

What is Haloperidol?

Rasuvo

Generic Name: methotrexate

Brand name: Methotrexate Sodium, Preservative Free, Otrexup, Rasuvo, Rheumatrex Dose Pack, Trexall, Xatmep

Synonyms: Rasuvo (injection), Rasuvo Injection

What is Rasuvo?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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