Haloperidol and Zyprexa

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using haloperidol together with OLANZapine may increase the blood levels or add to the side effects of either medication. Contact your doctor if you experience drowsiness, slurred speech, agitation, restlessness, convulsions, fever, an irregular heartbeat, or uncontrollable movements of the mouth, tongue, cheeks, jaw, arms or legs, or coma. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: In general, the concurrent use of multiple neuroleptic agents may increase the risk of adverse effects such as sedation, orthostatic hypotension, and extrapyramidal symptoms due to overlapping pharmacodynamic activities. In one case report, the combination of haloperidol and olanzapine was associated with severe parkinsonism in an elderly patient with a history of bipolar disorder. Prior to the addition of olanzapine, the patient had been stabilized on haloperidol and exhibited mild symptoms of parkinsonism that were controlled with benztropine. While hospitalized, a decision was made to switch from haloperidol to olanzapine in an attempt to minimize the parkinsonism. Over the next 7 days, olanzapine dosage was gradually increased while haloperidol dosage simultaneously decreased. The patient developed increased rigidity, mumbling speech, and inability to walk, which did not resolve until 3 days after the cessation of haloperidol. Benztropine was then discontinued, and symptoms did not recur while the patient was maintained on olanzapine alone.

MANAGEMENT: The use of multiple neuroleptic agents should be approached with caution. Patients should be monitored closely and advised to notify their physician if they experience excessive sedation, orthostasis, or extrapyramidal symptoms (e.g., dystonic reactions, akathisia, parkinsonism, neuroleptic malignant syndrome, tardive dyskinesia).

Haloperidol

Generic Name: haloperidol

Brand name: Haldol, Haldol Decanoate

Synonyms: n.a.

What is Haloperidol?

Zyprexa

Generic Name: olanzapine

Brand name: Zyprexa, Zyprexa Zydis, Zyprexa Intramuscular, Zyprexa Relprevv

Synonyms: n.a.

What is Zyprexa?