Haloperidol Decanoate and Methotrexate injection
Determining the interaction of Haloperidol Decanoate and Methotrexate injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:In an isolated case report, a man whose psoriasis had been well controlled on methotrexate for ten months developed pellagra-like photosensitive dermatitis two weeks following the addition of haloperidol. A possible interaction between methotrexate and haloperidol, combined with a deficiency of niacin, riboflavin and other water-soluble vitamins, was considered. The condition resolved within 5 days after discontinuation of haloperidol and initiation of multivitamin supplements, but reactivation occurred less than 24 hours after the next dose of methotrexate was given, probably due to photosensitivity recall phenomenon, which is an important but rarely encountered adverse effect of methotrexate. Treatment was stopped, and within one week, the dermatitis resolved. Methotrexate was restarted two weeks later without incident.
- Thami GP, Kaur S, Kanwar AJ "Delayed reactivation of haloperidol induced photosensitive dermatitis by methotrexate." Postgrad Med J 78 (2002): 116-7
Generic Name: haloperidol
Brand name: Haldol, Haldol Decanoate
Synonyms: Haloperidol
Generic Name: methotrexate
Brand name: Otrexup, Rasuvo, Rheumatrex Dose Pack, Trexall, Xatmep, Methotrexate Sodium, Preservative Free
Synonyms: Methotrexate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Haloperidol Decanoate-Methotrexate Injection (Subcutaneous)
- Haloperidol Decanoate-Methotrexate Oral Solution
- Haloperidol Decanoate-Methotrexate Oral, Injection
- Haloperidol Decanoate-Methotrexate Sodium
- Haloperidol Decanoate-Methotrexate Tablets
- Haloperidol Decanoate-Methoxsalen
- Methotrexate injection-Haloperidol Decanoate Injection
- Methotrexate injection-Haloperidol injection
- Methotrexate injection-Haloperidol Intramuscular
- Methotrexate injection-Haloperidol Lactate
- Methotrexate injection-Haloperidol Oral Solution
- Methotrexate injection-Haloperidol Oral Solution, Concentrate