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Haloperidol Decanoate and Rifadin

Determining the interaction of Haloperidol Decanoate and Rifadin and the possibility of their joint administration.

Check result:

Haloperidol Decanoate <> Rifadin

Relevance: 17.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Rifampin may reduce serum butyrophenone concentrations. The mechanism may be related to induction of CYP450 metabolism. Data exist only for rifampin, but this interaction may also occur with rifabutin. The clinical significance is unknown. Observation for alteration in response to haloperidol is indicated if these drugs must be used together.

References

Takeda M, Nishinuma K, Yamashita S, et al "Serum haloperidol levels of schizophrenics receiving treatment for tuberculosis." Clin Neuropharmacol 9 (1986): 386-97
Strayhorn VA, Baciewicz AM, Self TH "Update on rifampin drug interactions, III." Arch Intern Med 157 (1997): 2453-8
Borcherding SM, Baciewicz AM, Self TH "Update on rifampin drug interactions." Arch Intern Med 152 (1992): 711-6

Haloperidol Decanoate

Generic Name: haloperidol

Brand name: Haldol, Haldol Decanoate

Synonyms: Haloperidol

What is Haloperidol Decanoate?

Rifadin

Generic Name: rifampin

Brand name: Rifadin, Rifadin IV, Rimactane

Synonyms: n.a.

What is Rifadin?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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